Industry
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NAM Landscape by Country
Industry adopting NAM rapidly.
Industry leaders and organizations are driving the adoption of New Approach Methodologies (NAM) through innovative technologies, research, and advocacy. This section highlights companies and institutes advancing human-relevant, animal-free science in drug development and biomedical research. The list will be incremented as information becomes available.
Canada
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Note: The Canadian Centre for Alternatives to Animal Methods (CCAAM, est. 2017, University of Windsor) and its successor, the Canadian Institute for Animal-Free Science, have both ceased operations due to lack of sustained funding. Canada currently has no dedicated academic NAM centre or validation body.
NAM Platform and Biotech Developers
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Company
Location
NAM Work
Sources
Ananda Devices Canada
NeuroMuscle and NeuroHTS microfluidic human organ-on-a-chip platforms for neuromuscular and neurotoxicity screening (organ-on-chip)
PubMed validation study
Aspect Biosystems Vancouver, British Columbia
3D bioprinted human tissue models and bioprinted tissue therapeutics (bioprinting; in vitro)
BC Business ; BetaKit
Axolotl Biosciences Victoria, British Columbia
Stem-cell-based bioinks for 3D bioprinting of human tissues; TissuePrint product line (bioprinting)
TissuePrint
Epiloid Biotechnology
Toronto, Ontario
3D human cerebral organoid assays for neurological drug testing (organoids)
LinkedIn ; TMU Discovery Zone ; UTEST
Linearis Quebec City, Quebec
Multiplexed lab-on-a-chip organ-on-chip system for AI-driven drug discovery, developed with NRC and Mila (organ-on-chip; in silico)
Mila partnership ; CQDM funding
Neiges Biotechnologies
Montreal, Quebec
Lab-grown human miniature intestinal tissue models for drug discovery (organoids)
Front Row Ventures profile ; Dealroom
OrganoBiotech Hamilton, Ontario
Organ-on-chip platforms (blood vessel, lung, kidney, intestine, placenta); McMaster University spinoff (organ-on-chip)
McMaster CDCR
STEMCELL Technologies Vancouver, British Columbia
Dedicated NAMs product line; organoid and in vitro cell models for drug discovery and toxicology (in vitro)
NAM page ; Organoids and NAM
VascuBio Innovation Montreal, Quebec
Vascularized brain organoids-on-a-chip for anti-epileptic drug screening (organoids; organ-on-chip)
CQDM project
VoxCell BioInnovation Victoria, British Columbia
High-resolution vascularized 3D human tissue models for drug penetration, efficacy, and vascular-toxicity studies (bioprinting; in vitro)
Altasciences collaboration
In Silico and Computational Companies
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Company
Location
NAM Work
Sources
ACD/Labs Toronto, Ontario
Percepta platform and Tox Suite for in silico toxicity endpoint prediction (in silico)
Tox Suite
Chemical Computing Group Montreal, Quebec
Molecular modeling, simulation, and machine learning software (MOE) for computational toxicology (in silico)
Wikipedia
Cyclica Toronto, Ontario
AI-based predictive drug-discovery software modeling ligand-protein interactions (in silico); historical Canadian entity
BetaKit
Molecular Forecaster Montreal, Quebec
Computational chemistry software and CRO services for preclinical drug design (in silico)
Technoparc
profile
CROs Offering NAM Services
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Company
Location
NAM Work
Sources
Altasciences
Laval, Quebec
Early-phase CRO with dedicated NAM advisory services for toxicology programs; VoxCell collaboration (in vitro)
NAM page ; NAM study guide
Supporting Organizations
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Organization
Location
Role
Sources
Cosmetics Alliance Canada Toronto, Ontario
Industry association that supported the 2023 cosmetics animal-testing ban
Cosmetics Alliance
CQDM Montreal, Quebec
Quebec consortium funding collaborative NAM projects to reduce animal testing
CQDM announcement
oqCORE Ontario/Quebec
Ontario-Quebec Center for Organ-on-a-Chip Engineering; commercialization and validation pathways
CRAFT
United States
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NAM Platform and Biotech Developers
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Company
Location
NAM Work
Sources
Altis Biosystems United States
RepliGut human intestinal models from stem cells for predicting drug absorption, metabolism, and GI toxicity in people rather than animals (in vitro; organoids)
Publications ; CN Bio partnership
Emulate Boston, Massachusetts
Organ-on-a-chip technology recreating human physiology for drug development, disease modeling, and predictive toxicology; Harvard Wyss Institute spinoff (organ-on-chip)
Boston Globe
HemoShear Therapeutics Charlottesville, Virginia
REVEAL-Tx platform combining human tissue disease models with computational models of liver, tumor, and other tissues (in vitro; in silico)
Platform overview ; NIH SEED story
Hesperos Orlando, Florida
Human-on-a-chip multi-organ microphysiological systems for drug discovery, disease modeling, and safety testing (organ-on-chip)
GeneOnline ; BioPharm International
MatTek Ashland, Massachusetts
Reconstructed human tissue models (EpiDerm, RHE) for safety, efficacy, and toxicity testing; foundational Three Rs company (in vitro)
EpiDerm ; Three Rs history
Nortis / Numa Biosciences Seattle, Washington
Organ-on-chip devices growing human-derived cells in tissue-like structures for in vitro assays; merged into Numa Biosciences (NuVivo Organ-Chip) (organ-on-chip)
GeekWire
Organovo San Diego, California
3D bioprinted human tissue models for drug discovery and preclinical testing (bioprinting)
Wikipedia
Stemina Biomarker Discovery Madison, Wisconsin
Human iPSC-based in vitro assays (devTOX quickPredict, Cardio quickPredict) for developmental and cardiotoxicity screening (in vitro)
FDA document ; Contact and assay overview
Torch Bio Ann Arbor, Michigan
Patient-derived iPSC liver organoids combined with AI models for drug discovery (organoids; in silico)
University of Michigan Record
Visikol (acquired by CELLINK/BICO, 2021)Hampton, New Jersey
Contract research services in 3D cell culture, 3D tissue imaging, and digital pathology for pharma and biotech (in vitro; imaging)
BICO Group release ; ROI-NJ
In Silico and Computational Companies
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Supporting Organizations
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Organization
Location
Role
Sources
ICCVAM / NICEATM Research Triangle Park, North Carolina
US interagency committee coordinating the validation of alternative methods
Wikipedia
United Kingdom
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NAM Platform and Biotech Developers
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Supporting Organizations
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Organization
Location
Role
Sources
NC3Rs London
National Centre for the Replacement, Refinement and Reduction of Animals in Research; funds and promotes 3Rs research
Wikipedia
France
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NAM Platform and Biotech Developers
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Company
Location
NAM Work
Sources
Cherry Biotech Montreuil (Paris); founded in Rennes
Organ-on-chip and organoid culture platforms (CUBIX, Organ-on-Well) generating life-like preclinical data with AI analysis and live imaging (organ-on-chip; organoids)
Company story ; Atelerix partnership
Supporting Organizations
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Germany
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NAM Platform and Biotech Developers
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Supporting Organizations
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Organization
Location
Role
Sources
Bf3R / ZEBET Berlin
German Centre for the Protection of Laboratory Animals; ZEBET coordinates activities to limit animal testing and document alternative methods
BfR overview
Netherlands
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NAM Platform and Biotech Developers
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Company
Location
NAM Work
Sources
MIMETAS Oegstgeest (Leiden)
OrganoPlate organ-on-a-chip platforms for drug discovery and toxicity screening (organ-on-chip)
Company overview
Switzerland
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NAM Platform and Biotech Developers
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Supporting Organizations
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Organization
Location
Role
Sources
Swiss 3R Competence Centre Bern
National competence centre supporting development of alternatives to animal use and monitoring 3Rs implementation
Swiss 3RCC
Italy
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NAM Platform and Biotech Developers
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Supporting Organizations
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Organization
Location
Role
Sources
EURL ECVAM Ispra
EU Reference Laboratory for alternatives to animal testing, part of the European Commission Joint Research Centre; coordinates validation and regulatory acceptance of alternative methods across the EU
JRC EURL ECVAM page
Sweden
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NAM Platform and Biotech Developers
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Company
Location
NAM Work
Sources
BICO Group Gothenburg
Bioprinting and bioscience conglomerate (BIO X, CELLINK bioinks; acquired Visikol) enabling 3D cell models that reduce animal experiments (bioprinting; in vitro)
Wikipedia
