Organ on a Chip
929 words·5 mins
Organ-on-a-chip and microphysiological systems replicate human organ environments.
Advances
Credit: Mistral
New Approach Methodologies (NAM) represent a paradigm shift in biomedical research and drug development, replacing or supplementing traditional animal testing with human-relevant, in vitro, in silico, and in chemico technologies. The sections below synthesize peer-reviewed, validated medical discoveries enabled by NAM, organized thematically under the following areas.
Human Organoids
869 words·5 mins
Three dimensional stem cell cultures recapitulate human organ functions for research.
In Silico Modelling
497 words·3 mins
Computational models simulate human biology enabling virtual clinical trials.
AI for Drug Discovery
718 words·4 mins
AI analysis of vast datasets accelerate drug discovery through identification, prediction, and repurposing.
High Throughput Methods
388 words·2 mins
High-throughput technologies like CRISPR screens and multi-omics enable rapid drug target discovery.
Safety Assessments via NAM
589 words·3 mins
NAM provide human-relevant models for toxicity and safety assessment.