Advances

New Approach Methodologies (NAMs) represent a paradigm shift in biomedical research and drug development, replacing or supplementing traditional animal testing with human-relevant, in vitro, in silico, and in chemico technologies. This report synthesizes peer-reviewed, validated medical discoveries enabled by NAMs, organized thematically under the following 6 primary areas:

• Organ-on-a-Chip
• Human Organoids
• In Silico Modeling
• AI for Drug Discovery
• High-Throughput Methods
• Safety Assessment via NAM