Organ on a Chip
1607 words·8 mins
Organ-on-a-chip and microphysiological systems replicate human organ environments.
Advances
Credit: Mistral
New Approach Methodologies (NAM) represent a paradigm shift in biomedical research and drug development, replacing or supplementing traditional animal testing with human-relevant, in vitro, in silico, and in chemico technologies. The sections below synthesize peer-reviewed, validated medical discoveries enabled by NAM, organized thematically under the following areas.
Human Organoids
1284 words·7 mins
Three dimensional stem cell cultures recapitulate human organ functions for research.
In Silico Modelling
973 words·5 mins
Computational models simulate human biology enabling virtual clinical trials.
AI for Drug Discovery
1013 words·5 mins
AI analysis of vast datasets accelerate drug discovery through identification, prediction, and repurposing.
High Throughput Methods
822 words·4 mins
High-throughput technologies like CRISPR screens and multi-omics enable rapid drug target discovery.
Safety Assessments via NAM
1086 words·6 mins
NAM provide human-relevant models for toxicity and safety assessment.