Videos

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This section hosts a curated and growing collection of video content, including talks, presentations, and educational materials. The videos cover topics in New Approach Methodologies (NAM), in various areas such as AI, high-throughput, toxicology, safety assessment, organ-on-chip, organoids, and regulatory science.

Clips

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Brief, concise videos providing quick insights, explanations, or introductions to key concepts in NAM.

An introduction to new approach methodologies
Explains how traditional animal models in drug development are being replaced by NAM.

What Are Nonanimal Methods And Why Are They Important
A short video explaining the importance and benefits of non-animal testing methods.

Six Technologies That Help Stop the Use of Animals in Science
Overview of six human-relevant technologies replacing animals in scientific research.

Advanced Innovation Challenges: New Approach Methodologies (NAM)
Discussion on how NAM can replace, reduce, or refine animal use in the testing of medicinal products.

Non animal methods of research - a more humane and scientifically valid option
Dr. Andrew Knight discusses what options exist to replace animals in medical research.

Moving Beyond Animal Testing: An Intro to Non-Animal Methods
Introduction to non-animal testing methods and their benefits.

Toxicology to reduce the use of animals in research Fiona Sewell (NC3Rs) discusses reducing animal use in safety assessment.

Is toxicity testing using animals cheaper than non-animal methods?
Fact-checking video addressing the cost comparison between animal and non-animal testing methods. [The analysis is somewhat simplistic in that the costs can well exceed the 4x stated and the suggestion that animal testing keeps people safe is simply incorrect.]

Chemical safety: New approach methods and a future beyond
Explores the future of chemical safety testing using NAM.

Six Technologies That Help Stop the Use of Animals in Science
Overview of six human-relevant technologies replacing animals in scientific research.

Toxicology to reduce the use of animals in research
Fiona Sewell (NC3Rs) discusses reducing animal use in safety assessment.

New Approach Methodologies (NAMs)
International Fragrance Association continues support for shifting toward NAM to replace animal testing.

New Approach Methodologies (NAM) for human health risk assessment
Dr. Marescotti describes the development and application of NAM for human health risk assessments.

The Future of Drug Testing: Organ Chips in Action
Organ-on-a-Chip technology uses microfluidics, controlled shear stress, and chemical gradients to recreate realistic human tissue physiology on devices the size of a USB stick - often outperforming both traditional cell cultures and animal experiments in predicting drug toxicity and efficacy. The video covers the underlying physics and biology, multi-organ “body-on-a-chip” systems, and how AI and 3D bioprinting are advancing the field toward personalized medicine and a future “human-on-a-chip.”

Interviews

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One-on-one or small-group discussions with experts, researchers, and practitioners in the field of NAM.

Amy Clippinger and Mitch Klausner Discuss PETA Int’l Science Consortium and MatTek Collaborations
Discussion on collaborations to advance non-animal testing methods.

Kindfulness and Science
Dr. Charu Chandrasekera explains why it is important to cultivate mindfulness, kindness, compassion and kindfulness.

Organ Chip Engineering
Stem Cell Podcast chats with Dr. Milica Radisic, Guo, Professor and Canada Research Chair at the University of Toronto who uses organ-on-a-chip engineering to mimic physiology of the heart, kidney, and vasculature for the purpose of modeling human disease.

Talks

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Focused, informal presentations or keynote discussions highlighting specific aspects of NAM, such as case studies, innovations, or regulatory perspectives.

It’s Time to Think Outside the Cage
In this TEDx talk, Dr. Charu Chandrasekera explains that animal testing alternatives using NAM cost less, produce faster results, and being more human-relevant are more accurate.

This new technology could end animal testing
Sophie Leeman talks about NAM such as organ-on-a-chip offering a more ethical, physiologically relevant, and cost-effective alternative to traditional animal models for preclinical drug testing.

Engineered heart tissues for better health and longer life
Dr. Milica Radisic, PhD, PEng Professor at the University of Toronto’s Institute of Biomedical Engineering (IBBME), talks about advances in the fields of stem cells and tissue engineering that enable growth of fully functional human heart tissue. Such human-relevant advances could revolutionize drug discovery process and treatment of patients with heart disease.

New QSAR system to predict acute inhalation toxicity
Dr. Roustem Saiakhov of MultiCASE Inc. presents a new QSAR (Quantitative Struture-Activity Relationship) computational method system for predicting acute inhalation toxicity. This talk was for the 2018 PETA International Science Consortium series on non-animal inhalation testing methods.

NAM and In Silico approaches to the KCs
Dr. Kamel Mansouri (National Toxicology Program) discusses NAM and in silico approaches in this 2022 talk hosted by the UC Berkeley Superfund Research Program (SRP).

Lectures

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Formal, structured presentations and educational sessions focused on foundational and advanced topics in NAMs and toxicology.

Integration of New Approach Methods for Testing and Assessment Elisabet Berggren presents at the 1st National Congress on Alternatives to Animal Testing.

NAM and In Silico approaches to the KCs Dr. Kamel Mansouri (National Toxicology Program) discusses NAM and in silico approaches.

NAM in genotoxicity & mechanistic toxicity testing: Safety assessment of novel chemicals (May 2021)
Presenter: Giel Hendriks, CEO of Toxys, on the safety assessment of new compounds using NAM using ToxTracker and ToxProfiler, in vitro assays providing accurate, human-relevant toxicity information.

The Use of Machine Learning & Artificial Intelligence in Toxicology and Risk Assessment
Timothy E H Allen, Research Scientist, Willis Group, University of Cambridge explains how AI and ML algorithms can identify new patterns in data and make predictions in a way and on a scale that human scientists cannot.

SaferWorldbyDesign Webinar: In Silico Transporter Modeling and Its Role in Computational Toxicology
Gerhard F. Ecker, Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria discusses in silico transporter modeling in computational toxicology. This was a 2020 lecture presented by a partner of EU-ToxRisk Commercial Platform for New Approach Methods (NAMs) in Safety Assessment.

Eminent Toxicologist Lecture Series–From Murder to Mechanisms
Lecture by Michael A. Gallo on the history and evolution of toxicology and its relevance to modern NAM.

Eminent Toxicologist Lecture Series—Regulatory (Pharmaceutical) Toxicology
Lecture by Ruth A. Roberts on regulatory pharmaceutical toxicology and the role of NAM in drug safety testing.

How Can New Approach Methodologies Revolutionize Risk Assessment?
Explores how NAM are transforming chemical risk assessment with innovative, science-based alternatives. Dr. Brigit Mertens from Sciencano explores the opportunities of implementing NAM discussing the latest advancements in in silico modeling, high-throughput screening, organ-on-a-chip technology, and omics applications.

Intro to Smart In Silico Tools to Aid in Translating In Vitro & In Vivo Studies
Will Redfern introduces ToxStudio an integrated modelling and simulation platform which uses in silico tools for translating study results.

Navigating value-laden judgments about NAM in regulatory toxicology
European Chemicals Agency (ECHA) science seminar featuring Professor Kevin Elliott on value-laden judgments in NAM exploring how ethical and societal outlooks shape scientific reasoning.

Webinars

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Interactive online events, including webinars, panel discussions, and workshops, exploring the application, challenges, and advancements of NAM.

Moving Beyond Animal Testing: An Intro to Non-Animal Methods
Animal Alliance panel discuss non-animal testing methods and their benefits. The experts include Dr. Tara Barton-Maclaren from Health Canada, and Dr. Lorna Ewart CSO Emulate Inc.

Podcast: Why animal testing fails - the case for non-animal research methods
Discussion on why animal testing fails and the case for non-animal research methods.

Frameworks for Establishing Scientific Confidence in New Approach Methodologies: Part 1
Webinar on building scientific confidence in NAM, followed by a panel discussion.

Use of non animal skin sensitisation test methods
Webinar on human-relevant approaches to assess skin sensitization.

New approach method (NAM) : ICCVAM report & case study using branched carboxylic acids
Third webinar in the EPIC series on the use of NAM in risk assessment, hosted by PETA Science Consortium International e.V., and the U.S. EPA.

Day 1: New Approach Methodologies Workshop (May 31 - June 1)
ECHA workshop discussing critical needs to enable the transition to an animal-free regulatory system.

ICCVAM Public Forum - Interagency Coordinating Committee on the Validation of Alternative Methods, Session 1, May 20, 2024
Member agencies described their agencies’ activities both to advance new approaches to safety testing of chemicals. For more, see site.

Frameworks for Establishing Scientific Confidence in New Approach Methodologies: Part 1 Webinar on building scientific confidence in NAM, followed by a panel discussion.

NAM-based strategies for systemic toxicity assessment Webinar organized by PETA Science Consortium International e.V., and the Institute for In Vitro Sciences.

New approach method (NAM): ICCVAM report & case study using branched carboxylic acids Third webinar in the EPIC series on the use of NAM in risk assessment, hosted by PETA Science Consortium International e.V., and the U.S. EPA.

New Approaches for Fish Toxicity Testing
Dr. David Volz and Dr. Michelle Embry present on new approaches for fish toxicity testing using Adverse Outcome Pathways (AOP). This talk was hosted by the Physicians Committee for Responsible Medicine, US EPA, and PETA International Science Consortium Ltd., on the use of non-animal methods in risk assessment.

Advancing Eye Irritation Assessment with Non-Animal Methods for Chemicals
Fourth webinar in the EPIC series on the use of NAM in risk assessment with Lindsay O’Dell, US Environmental Protection Agency Office of Pesticide Programs, and Renee Beardslee, US Environmental Protection Agency Office of Pollution Prevention and Toxics. This talk is co-hosted by the U.S. Environmental Protection Agency (EPA), PETA Science Consortium International e.V., the Institute for In Vitro Sciences (IIVS), and the California Department of Pesticide Regulation (CDPR).

Acceptance and Use of In Vitro and Ex Vivo Eye Irritation Test Methods
Hans Raabe, MS, Institute for In Vitro Sciences, and João Barroso, PhD, European Commission, Joint Research Centre, discuss human-relevant approaches to assess eye irritation in this presentation part of a series hosted by the Physicians Committee for Responsible Medicine, US Environmental Protection Agency, and PETA Science Consortium International e.V., on the use of non-animal methods in risk assessment.

Regulatory tools for assessing the skin sensitization potential of chemicals and a case study
Sixth webinar in the EPIC series on the use of NAM in risk assessment, hosted by PETA Science Consortium International e.V., and the U.S. EPA.

New Approach Methodologies for personalized colorectal cancer treatment
Dr. George Ramzy, University of Geneva, Switzerland, presents his work on applying NAM to personalized colorectal cancer treatment. The presentation is part of the webinar on Replacement in Oncology Research and was organized by the Swiss 3RCC and the FC3R in 2024.

Advancing Regulatory Decision-Making Through New Approach Methods (NAM)
A session by Omari Bandele, PhD (FDA USA) on how NAM can advance regulatory decision-making.

Using NAM in Risk Assessment (September 2022)
Presenters: Katie Paul-Friedman, PhD (EPA USA) and George E. N. Kass (EPA USA), discuss the application of NAM in risk assessment.

Exploring AI’s potential to improve chemical safety
A 2026 interactive online workshop for industry professionals, policy experts, regulators and authorities, researchers, academics, and others who deal with chemical safety and circular economy issues.

Transitioning to animal-free cell culture media in India
Pratiksha Palahe of HiMedia Laboratories and Kamalnayan Tibrewal of Biokraft Foods provide an overview of the transition to animal-free chemically defined cell culture media. This webinar is presented by PETA India.

In Silico Toxicology 101: Computational Tools for Chemical Hazard Characterization
First webinar in a series on the use of in silico tools in toxicology organized by PETA Science Consortium International e.V., and the Institute for In Vitro Sciences.

In Silico Toxicology 101: Applications and Case Studies: Part I
Second webinar in a series on the use of in silico tools in toxicology organized by PETA Science Consortium International and the Institute for In Vitro Sciences.

In Silico Models: What to Do, What Not to Do
Webinar with Al Dossetter (Medchemica) covering best practices and pitfalls for in silico modeling.

Reducing the Number of Animals Used in Toxicology Studies
In this Altasciences webinar, Narine Lalyeva, MS and Dr. Norbert Makori, PhD focus on methods to minimize animal use in toxicology studies while ensuring scientific integrity.

In Vitro Models for Inhalation Toxicity Testing
Dr. Anna Maione of MatTek presents on in vitro models for inhalation toxicity testing in a 2018 PETA International Science Consortium e.V. webinar series on non-animal testing methods.

Precision-Cut Lung Slices (PCLS) – PETA Science Consortium Webinar
Dr. Holger Behrsing presents on precision-cut lung slices for toxicology testing in a 2018 PETA International Science Consortium e.V. webinar series on non-animal testing methods.

NAM-based strategies for systemic toxicity assessment
Katie Paul-Friedman (EPA USA) and Elisabet Berggren (European Commission JRC) present in this 2025 webinar organized by PETA Science Consortium International e.V., and the Institute for In Vitro Sciences.

Integration of New Approach Methods for Testing and Assessment
Elisabet Berggren presents at the 2018 1st National Congress on Alternatives to Animal Testing.

Use of computational approaches for pesticide toxicity assessment
In this 2023 webinar, Dr Bharath BR, Jai Research Foundation, and Dr Varun Ahuja, Syngene International Limited give an overview new approach methodologies and present a case study to demonstrating their use to evaluate the genotoxicity potential of pesticides.

Use of Non-Animal Methods for Skin Sensitization Testing
Susanne Kolle (BASF) and Taku Nishijou (Kao) present on non-animal testing strategies in this 2018 webinar hosted by PCRM, EPA and the PETA International Science Consortium Ltd., on the use of NAMs in risk assessment.

New approach methodologies: shaping research for non-animal test methods
ECHA’s 2024 initiatives in advancing non-animal testing methods through NAM with guests Sylvia Escher from the Fraunhofer Institute for Toxicology and Experimental Medicine, and Tomasz Sobanski from ECHA’s Alternative Methods Team.

State of the science for bioaccumulation: an integrated, weight of evidence approach
First webinar in a series on the use of NAM in ecotoxicology organized by the European Medicines Agency, the Health and Environmental Sciences Institute, the National Institute for Environmental Studies (NIES, Japan), PETA Science Consortium International e.V., the US Environmental Protection Agency, and the US Food and Drug Administration.

Gill cell line assay for acute fish toxicity prediction
Second webinar in a series on the use of NAM in ecotoxicology organised by the European Medicines Agency, the Health and Environmental Sciences Institute, the National Institute for Environmental Studies (NIES, Japan), PETA Science Consortium International e.V., the US Environmental Protection Agency, and the US Food and Drug Administration.

NAM Based Prediction of Respiratory Toxicity Using Human and Rat Airway Models
Charles River Laboratories and MatTek Life Sciences discuss NAM-based inhalation toxicology with Dr. Mary McElroy and Dr. Seyoum Ayehunie.

Implementing Computational Approaches for Regulatory Safety Assessments
ICCVAM 2024 Communities of Practice Webinar on computational approaches in regulatory safety.

Updates on Activities Related to 21st Century Toxicology
This webinar hosted by the Center for Alternatives to Animal Testing (CAAT) and the Animal-Free Safety Assessment Collaboration is an informal event providing brief updates on cutting edge approaches in toxicology.

Accelerating Drug Discovery with New Approach Methods (NAM)
This webinar explores how NAM are revolutionizing preclinical drug development with faster, cost-effective, and biologically relevant models. The speakers are Satish Sankaran Phd, Farcast Biosciences CSO, Jorge Urresti PhD, an Associate Director of iXCells Biotech, and Christopher Hughes PhD, Aracari Biosciences CSO.

New Approach Methods for Human Health Risk Assessment Meeting 1
A 2021(?) video on NAM titled “Variability and Relevance of Current laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods of use in Human Health Risk Assessment”.

New Approach Methods for Human Health Risk Assessment Meeting 12
A 2022 video on NAM titled “Variability and Relevance of Current laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods of use in Human Health Risk Assessment”.