NIH has launched the Office of Research Innovation, Validation, and Application (ORIVA) to coordinate efforts in developing, validating, and scaling New Approach Methodologies (NAMs), including 3D human tissue models and computational tools, to better reflect human biology and reduce animal use.
Key Highlights #
- ORIVA will coordinate NIH-wide efforts to advance human-based research technologies.
- The office aims to develop, validate, and scale NAMs, such as 3D human tissue models and computational tools.
- ORIVA will serve as a hub for interagency coordination and regulatory translation.
- The initiative seeks to reduce or replace animal use where appropriate, improving research replicability and translatability.
Statements #
Complex computational models, 3D human tissue models, and other emerging technologies have improved by leaps and bounds in recent years and may hold the key to a more effective research enterprise. — Jay Bhattacharya, M.D., Ph.D., NIH Director
NIH is committed to accelerating innovation and transparently assessing where animal use can be reduced or eliminated by transitioning to NAMs. — Nicole Kleinstreuer, Ph.D., NIH Deputy Director for Program Coordination, Planning, and Strategic Initiatives
About the Organizations #
National Institutes of Health (NIH) is the nation’s medical research agency, comprising 27 Institutes and Centers, and is the primary federal agency conducting and supporting basic, clinical, and translational medical research.
Learn More #
NIH Launches New Office to Advance Human-Based Research and Reduce Animal Use