Government

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This page highlights a growing list of governmental agencies and organizations worldwide that are at the forefront of advancing Safety Assessment via NAM (New Approach Methodologies). These bodies drive regulatory support, funding, and policy initiatives to promote toxicology innovation, reduce reliance on animal testing, and ensure safer, more ethical chemical and therapeutic evaluations. Their work underscores a global shift toward science-based, non-animal methods in safety assessment, reflecting a commitment to both human health and environmental responsibility.

Australian Industrial Chemicals Introduction Scheme (AICIS)
AICIS is Australia’s national regulator for the importation and manufacture of industrial chemicals, actively supporting the adoption of NAM for chemical safety assessments and aligning with international best practices.

Australian Therapeutic Goods Administration (TGA)
The TGA regulates therapeutic goods in Australia and promotes the use of NAM in the evaluation of medicines and medical devices, ensuring safety and efficacy without animal testing.

European Commission - Joint Research Centre (JRC)
The JRC provides scientific support to EU policies, including the development, validation, and implementation of NAM for chemical safety assessment and regulatory frameworks.

European Food Safety Authority - EFSA
An independent European agency providing robust scientific opinions, risk assessments, and dedicated computational suites (like OpenFoodTox and TKPlate) to advance safety criteria across the food and feed sectors.

European Union Reference Laboratory for Alternatives to Animal Testing
EURL ECVAM coordinates the validation of alternative test methods and promotes NAM in regulatory toxicology across the EU, providing scientific and technical support to policymakers.

Japanese Center for the Validation of Alternative Methods (JaCVAM)
JaCVAM coordinates the validation and acceptance of alternative test methods in Japan, supporting regulatory adoption of NAM.

Korea Center for the Validation of Alternative Methods (KoCVAM) KoCVAM works to validate and implement NAM in regulatory toxicology, ensuring alignment with global standards.

Ombion Centre for Animal-free Biomedical Translation
The CPBT at Utrecht University is a global leader in developing and promoting non-animal testing methods, with a strong focus on the 3Rs (Replacement, Reduction, Refinement) and cutting-edge research in toxicology and biomedical sciences.

Organisation for Economic Co-operation and Development (OECD)
The OECD develops and harmonizes test guidelines for chemical safety, including NAM, to facilitate global regulatory acceptance and reduce animal testing.

UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
NC3Rs funds and promotes research to replace, refine, and reduce the use of animals in scientific procedures, with a strong emphasis on NAM.

U.S. Environmental Protection Agency - EPA
A federal regulatory agency actively executing explicit, multi-year strategic work plans and computational data infrastructure upgrades under TSCA and FIFRA to significantly reduce and phase out vertebrate testing.

U.S. Food and Drug Administration (FDA) - New Approach Methodologies (NAMs)
The FDA supports the adoption of NAM in drug development and regulatory submissions, encouraging innovative, non-animal testing methods for safety and efficacy evaluations.

U.S. Food and Drug Administration (FDA) - Center for Drug Evaluation and Research (CDER)
CDER supports the adoption of NAM in drug development and regulatory submissions, encouraging innovative, non-animal testing methods for safety and efficacy evaluations.

U.S. Interagency Coordinating Committee on the Validation of Alternative Methods - ICCVAM
A prominent collaborative framework composed of 16 U.S. federal regulatory and research agencies, tasked with establishing scientific confidence, coordinating test-method readiness criteria, and accelerating the global regulatory uptake of human-relevant alternatives.

U.S. National Institutes of Health (NIH) - National Center for Advancing Translational Sciences (NCATS)
NCATS supports the development and adoption of NAM through research, funding, and collaboration, focusing on translational science to improve human health.

U.S. National Toxicology Program (NTP)
The NTP coordinates toxicology research and testing across U.S. federal agencies, promoting the use of NAM to assess chemical safety and reduce animal testing.